|
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our meta-analysis demonstrated that the rs11209026 polymorphism might be a protective factor against developing IBD, while the rs10889677 polymorphism might be a risk factor for IBD.
|
31728561 |
2020 |
|
rs7134599
|
|
|
0.810 |
GeneticVariation |
BEFREE |
The significance of these results is amplified by studies suggesting that a single nucleotide polymorphism in IFNG-AS1, rs7134599, was associated with both subtypes of IBD patients independently of race.
|
31545920 |
2020 |
|
rs2241880
|
|
|
0.070 |
GeneticVariation |
BEFREE |
SNPs rs1800896, rs3024505 (IL-10); rs11209026 (IL23R); rs2066844, rs2066845 (NOD-2), and rs2241880 (ATG16L1) were assessed in 93 patients with IBD and 200 healthy controls by hybridization probes and quantitative PCR.
|
31651650 |
2020 |
|
rs10889677
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our meta-analysis demonstrated that the rs11209026 polymorphism might be a protective factor against developing IBD, while the rs10889677 polymorphism might be a risk factor for IBD.
|
31728561 |
2020 |
|
rs111033623
|
|
|
0.010 |
GeneticVariation |
BEFREE |
HSCT is the only curative therapy for XLP and this therapy should be urgently considered.What is Known:• SAP and XIAP deficiencies share common clinical feature, HLH, whereas they also have their own specific manifestations.• IBD affects 25-30% of XIAP-deficient patients, which has been reported in other countries especially in European country and Japan.What is New:• This is the largest patient cohort study of XLP in China.• We firstly summarized the clinical features and outcomes of Chinese XIAP-deficient patients and found only 1 in 22 patients developed IBD and diet background may contribute to it; Asian SAP-deficient patients carrying SH2D1A R55X mutation were more prone to HLH.
|
31754776 |
2020 |
|
rs2097432
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To evaluate the association between HLADQA1*05 and infliximab antibody formation, infliximab loss of response, treatment discontinuation and adverse drug events in patients with inflammatory bowel disease (IBD) METHODS: In a retrospective cohort study, infliximab-exposed patients with IBD (n = 262) were screened for the genetic variation, HLADQA1*05A>G (rs2097432).
|
31650614 |
2020 |
|
rs10500264
|
|
|
0.820 |
GeneticVariation |
BEFREE |
One SNP (rs4986791 in the TLR-4 locus) and 2 SNPs (rs6785049 in the Pregnane-x-receptor gene and rs10500264 in the SLCA10 gene) were associated with a change in albumin and hemoglobin over time respectively in our IBD cohort.
|
30423580 |
2019 |
|
rs8005161
|
|
|
0.810 |
GeneticVariation |
BEFREE |
The T allele of rs8005161 might confer a more severe disease course in IBD patients.
|
30616622 |
2019 |
|
rs116855232
|
|
|
0.750 |
GeneticVariation |
BEFREE |
Our results indicate that careful monitoring of leukopenia and dose adjustment are necessary throughout treatment in IBD patients heterozygous for the NUDT15 R139C.
|
31045285 |
2019 |
|
rs11969064
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease.
|
30806694 |
2019 |
|
rs4986790
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, the TLR4 rs4986790 polymorphism was significantly correlated with the risk of IBD in West Asians, while the TLR9 rs352140 polymorphism was significantly associated with the risk of IBD in Africans.
|
30617966 |
2019 |
|
rs4986791
|
|
|
0.080 |
GeneticVariation |
BEFREE |
One SNP (rs4986791 in the TLR-4 locus) and 2 SNPs (rs6785049 in the Pregnane-x-receptor gene and rs10500264 in the SLCA10 gene) were associated with a change in albumin and hemoglobin over time respectively in our IBD cohort.
|
30423580 |
2019 |
|
rs2292832
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Previous studies have linked miRNA-149 to cancers, and rs2292832 T>C is related to allergic diseases and inflammatory bowel disease, which both show immune system disorders and coronary artery disease.
|
31785027 |
2019 |
|
rs2501432
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The CB2-Q63R variant contributes to the risk for pediatric IBD, in particular CD.
|
27875353 |
2019 |
|
rs352140
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Moreover, the TLR4 rs4986790 polymorphism was significantly correlated with the risk of IBD in West Asians, while the TLR9 rs352140 polymorphism was significantly associated with the risk of IBD in Africans.
|
30617966 |
2019 |
|
rs35761398
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The CB2-Q63R variant contributes to the risk for pediatric IBD, in particular CD.
|
27875353 |
2019 |
|
rs601338
|
|
|
0.020 |
GeneticVariation |
BEFREE |
CONCLUSIONS Fucosyltransferase 2 gene (rs601338) polymorphism is associated with susceptibility to IBD, UC, and CD in the Chinese population, but these results might not be generalizable to other ethnic populations.
|
30615603 |
2019 |
|
rs6785049
|
|
|
0.020 |
GeneticVariation |
BEFREE |
One SNP (rs4986791 in the TLR-4 locus) and 2 SNPs (rs6785049 in the Pregnane-x-receptor gene and rs10500264 in the SLCA10 gene) were associated with a change in albumin and hemoglobin over time respectively in our IBD cohort.
|
30423580 |
2019 |
|
rs731236
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the association of the TaqI polymorphism (rs731236, c.1056T >C) in the VDR gene with serum vitamin D concentration and bone mineral density (BMD) in patients with IBD.
|
30929318 |
2019 |
|
rs879761216
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The CB2-Q63R variant contributes to the risk for pediatric IBD, in particular CD.
|
27875353 |
2019 |
|
rs200550971
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The CB2-Q63R variant contributes to the risk for pediatric IBD, in particular CD.
|
27875353 |
2019 |
|
rs2413739
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of the study was to validate the impact of the single-nucleotide polymorphism rs2413739 (T > C) in the PACSIN2 gene on thiopurines pharmacological parameters and clinical response in an Italian cohort of pediatric patients with acute lymphoblastic leukemia (ALL) and inflammatory bowel disease (IBD).
|
31792371 |
2019 |
|
rs3129891
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mutant genotypes at rs2066844, rs2066845, rs2066847 were not found, and only SNPs rs3129891 and rs77005575 were associated with enteric α-defensin expression in colonic IBD.
|
31403980 |
2019 |
|
rs34436714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association between genotypes of rs34436714 of NLRP12 and serum tumor necrosis factor-alpha in inflammatory bowel disease: A case-control study.
|
31169706 |
2019 |
|
rs5743611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significant associations with the risk of IBD were detected for the TLR1 rs5743611, TLR4 rs4986790, TLR4 rs4986791, and TLR6 rs5743810 polymorphisms in overall analyses.
|
30617966 |
2019 |